Multitarget AD-IN-3
Multitarget AD-IN-3 is a brain-penetrant neuroprotective agent. Multitarget AD-IN-3 can selectively inhibit MAO-B with an IC50 of 4.42 μM and a SI of 18.12. Multitarget AD-IN-3 can eliminate ROS. Multitarget AD-IN-3 Multitarget AD-IN-3 can inhibit Aβ1-42 self-aggregation and can reverse Aβ1-42-induced mitochondrial membrane depolarization and inhibit apoptosis. Multitarget AD-IN-3 can be used for the research of neurological disease, such as Alzheimer’s disease[1].
Product Specifications
UNSPSC
12352005
Target
Amyloid-β; Apoptosis; COX; Mitochondrial Metabolism; Monoamine Oxidase; NF-κB; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C(N/N=C/C1=CC=CN1)C(N=NN2C(C=C3)=CC=C3NC(/C=C/C(O)=O)=O)=C2C
Molecular Formula
C19H17N7O4
Molecular Weight
407.38
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX; MAO-A; MAO-B
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