VEGFR-2-IN-74

VEGFR-2-IN-74 (compound 55) is a potent VEGFR-2 inhibitor (IC50 = 0.035 µM) . VEGFR-2-IN-74 exhibits good anti proliferative activity and can induce apoptosis in various cancer cells, such as A549 (IC50 = 2.67 µM) and HCT116 (IC50 = 10.87 µM) cells. VEGFR-2-IN-74 has low toxicity to normal cells. VEGFR-2-IN-74 shows significant anti angiogenic effects in chicken embryo models. VEGFR-2-IN-74 can be used in the research of cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; VEGFR

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(NC)C1=CC=C(OCC2=CC=C(NC(NC(N3)=NC(C)C4=C3CCCC4=O)=O)C=C2)C=C1

Molecular Formula

C25H27N5O4

Molecular Weight

461.51

References & Citations

[1]Siddique A, et al. Bicyclic 2-aminopyrimidine derivatives as potent VEGFR-2 inhibitors and apoptosis Inducers: Structure-Guided design, synthesis, anticancer assessment, and in-silico exploration. Eur J Med Chem. 2025 Sep 5;293:117726.