PROTAC CDK4/6/9 degrader 1

PROTAC CDK4/6/9 degrader 1 is a CDK4/6/9 PROTAC degrader. PROTAC CDK4/6/9 degrader 1 degrades CDK4, CDK6, and CDK9 in TNBC cells and inhibits TNBC cell proliferation. PROTAC CDK4/6/9 degrader 1 induces G1 phase arrest, promotes apoptosis, and suppresses cell migration and invasion in TNBC cells. PROTAC CDK4/6/9 degrader 1 can be used for the study of triple-negative breast cancer (TNBC) . (Pink: CDK4/6/9 ligand (HY-168440), Blue: CRBN Ligand (HY-14658), Black: Linker (HY-178512), E3 ligase ligand-linker conjugate (HY-178515) ) [1].

Product Specifications

CAS Number

[3064994-97-1]

UNSPSC

12352005

Target

Apoptosis; CDK; PROTACs

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; PROTAC

Field of Research

Cancer

Smiles

O=C(C1=CC2=C(N=C(N=C2)NC3=CC=C(C=C3)C(CN4CCN(CC4)CC5CCN(CC5)CC(N6CCN(CC6)C7=CC=C(C8=C7)C(N(C8=O)C9CCC(NC9=O)=O)=O)=O)=O)N1C%10CCCC%10)N(C)C

Molecular Formula

C51H62N12O7

Molecular Weight

955.11

References & Citations

[1]Hu H, et al. Translational Research on the Oral Delivery of the Cytotoxic PROTAC Molecule via Tumor-Targeting Prodrug Strategy for Triple-Negative Breast Cancer Treatment. J Med Chem. 2025 Oct 9;68 (19) :20464-20486.