HW091077
HW091077 is a highly selective P2X3 receptor antagonist with an IC50 of 17 nM. HW091077 blocks ATP-induced calcium influx and cell depolarization to inhibit cough reflex pathways. HW091077 is promising for research of chronic cough[1].
Product Specifications
CAS Number
2766757-56-4
UNSPSC
12352005
Target
P2X Receptor
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Smiles
FC1=C(C2=NC=C(C)S2)C=C(C=C1C(N[C@@H](C3=CN=C(C(F)(F)F)N=C3)C)=O)O[C@@H](C)[C@@H](O)C
Molecular Formula
C22H22F4N4O3S
Molecular Weight
498.49
References & Citations
[1]Zang Y, et al. Development of a P2X3 receptor antagonist derived from eliapixant with improved properties for the treatment of chronic cough. Eur J Med Chem. 2025 Dec 15;300:118116.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2X2 Receptor
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