METTL3-IN-11

METTL3-IN-11 is an excellent, selective METTL3 inhibitor (IC50 = 45.31 nM) . METTL3-IN-11 exhibits high selectivity towards METTL3 compared to DNMT1, EZH1, MLL1, and PRMT1. METTL3-IN-11 reduces the m6A level of total RNA in MOLM-13 and SKOV3 cells, induces cell apoptosis, and inhibits cell migration. METTL3-IN-11 can reduce the expression of m6A downstream target genes (c-MYC and BCL2) . METTL3-IN-11 can be used for the study of ovarian cancer and acute myeloid leukemia[1].

Product Specifications

CAS Number

[3069369-05-4]

UNSPSC

12352005

Target

Bcl-2 Family; c-Myc; METTL3

Related Pathways

Apoptosis; Epigenetics

Field of Research

Cancer

Smiles

OC1=C(CN2C=NC(C(NCC3=CN4C(C=CC(CNCC5CCC5)=C4)=N3)=O)=CC2=O)C=CC=C1

Molecular Formula

C26H28N6O3

Molecular Weight

472.54

References & Citations

[1]Miao R, et al. Identification of novel 2, 6-Di-substituted Imidazo[1,2-a]pyridine derivatives as potent METTL3 inhibitors. Bioorg Chem. 2025 Oct;165:108980.