Pim-1 kinase-IN-15
Pim-1 kinase-IN-15 (Compound 15) is a highly potent and selective Pim-1 kinase inhibitor (IC50=0.212 μM) . Pim-1 kinase-IN-15 induces tumor cell apoptosis and suppresses cell migration. Pim-1 kinase-IN-15 is promising for research of oncology, such as breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Pim
Related Pathways
Apoptosis; JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1N(CC(N/N=C2C(C=CC=C3)=C3CC/2)=O)C=NC4=C1C(CC5)=C(S4)CN5CC6=CC=CC=C6
Molecular Formula
C27H25N5O2S
Molecular Weight
483.58
References & Citations
[1]Sayed MTM, et al. Design and synthesis of new Thieno[2,3-d]pyrimidine-based derivatives as anti-breast cancer: Biological evaluation, PIM-1 kinase inhibition, and in silico studies. Bioorg Chem. 2025 Oct;165:109003.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PIM1
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