EGFR-IN-179
EGFR-IN-179 (Compound 8d) is an EGFR inhibitor (IC50: 0.068 μM for EGFR L858R/T790M/C797S; 2.56 μM for EGFR-WT-TK) . EGFR-IN-179 has anticancer activity against non-small cell lung cancer[1].
Product Specifications
CAS Number
3078678-28-8
UNSPSC
12352005
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
OS(C(C(C=CC=C1)=C1C=C2)=C2NC3=NC(NCC4=CC=CO4)=C(C=CC=C5)C5=N3)(=O)=O
Molecular Formula
C23H18N4O4S
Molecular Weight
446.48
References & Citations
[1]Patil BR, et al. Quinazoline-based fourth-generation EGFR tyrosine kinase inhibitors to overcome C797S-mediated resistance in non-small cell lung Cancer (NSCLC) . Bioorg Chem. 2025 Oct;165:108991.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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