EGFR-IN-179

EGFR-IN-179 (Compound 8d) is an EGFR inhibitor (IC50: 0.068 μM for EGFR L858R/T790M/C797S; 2.56 μM for EGFR-WT-TK) . EGFR-IN-179 has anticancer activity against non-small cell lung cancer[1].

Product Specifications

CAS Number

[3078678-28-8]

UNSPSC

12352005

Target

EGFR

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

OS(C(C(C=CC=C1)=C1C=C2)=C2NC3=NC(NCC4=CC=CO4)=C(C=CC=C5)C5=N3)(=O)=O

Molecular Formula

C23H18N4O4S

Molecular Weight

446.48

References & Citations

[1]Patil BR, et al. Quinazoline-based fourth-generation EGFR tyrosine kinase inhibitors to overcome C797S-mediated resistance in non-small cell lung Cancer (NSCLC) . Bioorg Chem. 2025 Oct;165:108991.