PKM2-IN-11

PKM2-IN-11 is a PKM2 inhibitor (IC50 = 0.363 μM) . PKM2-IN-11 has dual mechanisms involving pyruvate kinase M2 (PKM2) inhibition and microtubule stabilization. PKM2-IN-11 can decrease PKM2 protein levels in MCF-7 cells. PKM2-IN-11 can slightly reduce reactive oxygen species (ROS) levels and significantly increase early apoptotic cells. PKM2-IN-11 induces G2/M phase arrest. PKM2-IN-11 can be used for the study of breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin; Pyruvate Kinase; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer; Metabolic Disease

Smiles

CC1(C)C=CC2=C(C=CC(/C=C/C(C3=CC=C(OC)C(I)=C3)=O)=C2O)O1

Molecular Formula

C21H19IO4

Molecular Weight

462.28

References & Citations

[1]Katiyar MK, et al. Mechanism-guided discovery of chromene-chalcone hybrids targeting PKM2 and microtubules for breast cancer therapy. Bioorg Chem. 2025 Oct;165:109008.