EGFR/COX-2-IN-2

EGFR/COX-2-IN-2 (Compound 10a) is a dual inhibitor targeting epidermal growth factor receptor (EGFR) (IC50= 6.0 μM) and cyclooxygenase-2 (COX-2) (IC50=50 μM) . EGFR/COX-2-IN-2 induces S-phase cell cycle arrest and apoptosis. EGFR/COX-2-IN-2 is promising for research of cancers and inflammation-related diseases[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; COX; EGFR

Related Pathways

Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=C(NCC1=CC=CC=C1)C(C=C2C3=CC=CC=C3)=NN2C(C=C4)=CC=C4S(=O)(N)=O

Molecular Formula

C23H20N4O3S

Molecular Weight

432.49

References & Citations

[1]Soltan OM, et al. Design, synthesis, and biological evaluation of novel 1,5-diarylpyrazole carboxamides with dual inhibition of EGFR and COX-2 for the treatment of cancer and inflammatory diseases. Bioorg Med Chem Lett. 2025 Sep 20;130:130416.