SARS-CoV-2 3CLpro-IN-33

SARS-CoV-2 3CLpro-IN-33 (Compound 16) is an orally active SARS-CoV-2 3CL protease inhibitor, with an IC50 value of 1.5 nM. SARS-CoV-2 3CLpro-IN-33 shows excellent anti-SARS-CoV-2 viral activity in the HEK293T-AT cell model with an EC50 of 0.017 μM. SARS-CoV-2 3CLpro-IN-33 can be used for the study of COVID-19 infetction[1].

Product Specifications

CAS Number

[2920182-91-6]

UNSPSC

12352005

Target

SARS-CoV

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

CN1C=NC(CN2C(C3=C(N(C2=O)CC4=CC(F)=C(C(F)=C4)F)C=C(C5=C3OCC5)C6=CC(C#N)=CC=C6Cl)=O)=N1

Molecular Formula

C28H18ClF3N6O3

Molecular Weight

578.93

References & Citations

[1]Taoda Y, et al. Design, synthesis and biological evaluation of novel quinazolinedione derivatives as non-covalent SARS-CoV-2 3CL protease inhibitors. Bioorg Med Chem Lett. 2025 Dec 15;129:130400.