Mer/c-Met-IN-1

Mer/c-Met-IN-1 is a potent Mer/c-met dual inhibitor with IC50 values of 1 and 19 nM. Mer/c-Met-IN-1 can inhibit cancer cells proliferation, migration and induce apoptosis. Mer/c-Met-IN-1 can be used for the research of cancer, such as colon cancer[1].

Product Specifications

CAS Number

[3062159-91-2]

UNSPSC

12352005

Target

Apoptosis; c-Met/HGFR

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

CN1CCN(CC1)C2=CC(NC3=NC(OC4=CC=C(C=C4)NC(C5=CN(C=C(C5=O)C6=CC=C(C=C6)F)CC7CCCO7)=O)=CC=N3)=CC=C2

Molecular Formula

C38H38FN7O4

Molecular Weight

675.75

References & Citations

[1]Duan L, et al. Design, synthesis, and biological evaluation of novel potent dual Mer/c-Met inhibitors based on structural optimization. Bioorg Med Chem Lett. 2025 Sep 20;130:130415.