Mer/c-Met-IN-1
Mer/c-Met-IN-1 is a potent Mer/c-met dual inhibitor with IC50 values of 1 and 19 nM. Mer/c-Met-IN-1 can inhibit cancer cells proliferation, migration and induce apoptosis. Mer/c-Met-IN-1 can be used for the research of cancer, such as colon cancer[1].
Product Specifications
CAS Number
3062159-91-2
UNSPSC
12352005
Target
Apoptosis; c-Met/HGFR
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CN1CCN(CC1)C2=CC(NC3=NC(OC4=CC=C(C=C4)NC(C5=CN(C=C(C5=O)C6=CC=C(C=C6)F)CC7CCCO7)=O)=CC=N3)=CC=C2
Molecular Formula
C38H38FN7O4
Molecular Weight
675.75
References & Citations
[1]Duan L, et al. Design, synthesis, and biological evaluation of novel potent dual Mer/c-Met inhibitors based on structural optimization. Bioorg Med Chem Lett. 2025 Sep 20;130:130415.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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