Bastadins-5

Bastadins-5 is a potent stabilizer for the open state of RYR1. Bastadins-5 enhances Ca2+-induced Ca2+ release. Bastadins-5 can be used in research on central nuclear disease and malignant hypothermia[1].

Product Specifications

CAS Number

[79067-75-7]

UNSPSC

12352005

Target

Calcium Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Metabolic Disease

Smiles

BrC1=C(O)C2=CC(C/C(C(NCCC3=CC(Br)=C(OC4=C(C(Br)=CC(CCNC(/C(CC5=CC(Br)=C(C(Br)=C5)O2)=N/O)=O)=C4)O)C=C3)=O)=N/O)=C1

Molecular Formula

C34H27Br5N4O8

Molecular Weight

1019.12

References & Citations

[1]Franklin MA, et al. Structure-activity of Bastadins from the marine sponge Ianthella basta. Modulators of the RYR1 Ca2+ channel. Bioorg Med Chem Lett. 2025 Jun 1;121:130165.