BChE/p38-α MAPK-IN-2

BChE/p38-α MAPK-IN-2 is a BChE and p38-α MAPK dual inhibitor. BChE/p38-α MAPK-IN-2 inhibits hBChE with an IC50 of 5.1 nM, showing 1000-fold selectivity over hAChE. BChE/p38-α MAPK-IN-2 inhibits p38α MAPK with an IC50 of 8.12 μM. BChE/p38-α MAPK-IN-2 exhibits neuroprotective effect and can be used for the research of neurological disease, such as Alzheimer’s disease[1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE) ; p38 MAPK

Related Pathways

MAPK/ERK Pathway; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

CC(NCC(NCC1=CC=CC(N2N=C(C=C2OC(N(CC3=CC=CC=C3)C)=O)C(C)(C)C)=C1)=O)=O

Molecular Formula

C27H33N5O4

Molecular Weight

491.58

References & Citations

[1]Benetik SF, et al. Transforming ureas into carbamates: From allosteric p38α MAPK ligands to dual BChE/p38α MAPK inhibitors. Bioorg Chem. 2025 Oct;165:108998.