SHMT2-IN-1
SHMT2-IN-1 is a potent serine hydroxymethyltransferase 2 (SHMT2) inhibitor with an IC50 of 1.21 μM and a KD of 10.6 μM. SHMT2-IN-1 binds to the folate binding site of SHMT2. SHMT2-IN-1 also inhibits SHMT1 with an IC50 of 1.83 μM. SHMT2-IN-1 can inhibit cancer cells proliferation, migration and invasion. SHMT2-IN-1 can induce cells apoptosis and ROS production and cause G2/M phase arrest. SHMT2-IN-1 can be used for the research of cancer, such as esophageal cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Reactive Oxygen Species (ROS) ; SHMT
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
N#CC1=C(N=C(N=C1C2=CC=C(C=C2)Cl)SCC3=CC=C(C=C3)C(O)=O)SC4=NN=NN4C5=CC=CC=C5
Molecular Formula
C26H16ClN7O2S2
Molecular Weight
558.03
References & Citations
[1]Akram HMB, et al. Discovery of W478, a novel SHMT2 inhibitor for the treatment of esophageal carcinoma. Bioorg Chem. 2025 Oct;165:109028.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SHMT1
Available Sizes
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