GnRH-R antagonist-2
GnRH-R antagonist-2 (Compound 44c) is a Gonadotropin releasing hormone receptor (GnRH-R) antagonist with IC50s of 43 and 88 nM for rat and human GnRH-R, respectively. GnRH-R antagonist-2 can be used for hormone dependent diseases such as endometriosis, breast and prostate cancer research[1].
Product Specifications
CAS Number
1000819-21-5
UNSPSC
12352005
Target
GnRH Receptor
Related Pathways
GPCR/G Protein
Field of Research
Cancer
Smiles
O=C(C1CCN(CC1C)CCC2=C(C3=CC(C)=CC(C)=C3)NC4=C2C=C(C(C)(C)C(N5C6CCC5CC6)=O)S4)N7CCOCC7
Molecular Formula
C37H50N4O3S
Molecular Weight
630.88
References & Citations
[1]Arnould JC, et al. Synthesis and structure-activity relationships of thieno[2,3-b]pyrroles as antagonists of the GnRH receptor. Bioorg Med Chem Lett. 2007 Dec 1;17 (23) :6448-54.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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