Angustilongine M

Angustilongine M is a microtubule-targeting antitumor alkaloid (IC50=0.2 μM against HT-29 cells) . Angustilongine M induces G0/G1 cell cycle arrest and mitochondrial apoptosis via tubulin polymerization promotion. Angustilongine M is promising for research of colorectal cancer and other solid tumors[1].

Product Specifications

CAS Number

[2732914-43-9]

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Smiles

C[C@H]1C2=C(O[C@@]3([H])[C@]1([H])[C@@]4([H])[C@@]([C@]5([H])CC6=C(N(C7=CC=CC=C76)C)[C@](N5C)([H])C4)([H])CO3)C=CC8=C2C9=C([C@@]%10([H])[N@@]%11[C@@]([C@@H]([C@](/C(C%11)=C\C)([H])C%10)CO)([H])C9)N8C

Molecular Formula

C41H48N4O3

Molecular Weight

644.84

References & Citations

[1]Tan CH, et al. The Bisindole Alkaloids Angustilongines M and A from Alstonia penangiana Induce Mitochondrial Apoptosis and G0/G1 Cell Cycle Arrest in HT-29 Cells through Promotion of Tubulin Polymerization. J Nat Prod. 2021 May 28;84 (5) :1524-1533.