TRPM2-IN-2
TRPM2-IN-2 is a potent and selective TRPM2 inhibitor (IC50 = 0.66 μM) with minimal activity against TRPM8 and TRPV1 (IC50 >10 μM) . TRPM2-IN-2 exhibits robust neuroprotective effects in both in vitro oxygen-glucose deprivation/reperfusion (OGD/R) model and in vivo transient middle cerebral artery occlusion (tMCAO) mouse model. TRPM2-IN-2 can be used for ischemic stroke research[1].
Product Specifications
UNSPSC
12352005
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Neurological Disease; Metabolic Disease
Smiles
O=C(N1CCCC1)C2=CC3=CC=CN3C(C(NC4(C[C@H]5C6)C[C@H]6C[C@H](C5)C4)=O)=C2
Molecular Formula
C24H29N3O2
Molecular Weight
391.51
References & Citations
[1]Lu T, et al. Discovery of adamantyl derivatives as potent and selective TRPM2 inhibitors with significantly reduced hERG liability. Eur J Med Chem. 2025 Dec 15;300:118172.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPM2
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