GPX4-IN-20

GPX4-IN-20, a Arctigenin (HY-N0035) derived, is a GPX4& molecular gluedegrader. GPX4-IN-20 induces ferroptosis by increasing lipid ROS levels and suppressing GSH levels. GPX4-IN-20 reduces the protein expression and enzyme activity of GPX4 in a dose-dependent manner without affecting other ferroptosis-related proteins. GPX4-IN-20 induces ubiquitination-dependent proteasomal degradation of GPX4. GPX4-IN-20 also increases the level of malondialdehyde (MDA) in HCT-116 cells. GPX4-IN-20 can be used for the research of colorectal cancer[1].

Product Specifications

UNSPSC

12352005

Target

Ferroptosis; Glutathione Peroxidase; Molecular Glues; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

ClCC(NC(C=C1)=CC=C1C(OC(C(OC)=C2)=CC=C2C[C@@H](C(OC3)=O)[C@H]3CC4=CC(OC)=C(OC)C=C4)=O)=O

Molecular Formula

C30H30ClNO8

Molecular Weight

568.01

References & Citations

[1]Wang YX, et al. Design, synthesis, and biological evaluation of arctigenin derivatives as novel GPX4 inhibitors in colorectal cancer cells. Eur J Med Chem. 2025;300:118181.