α-Glucosidase-IN-98

α-Glucosidase-IN-98 is a potent orally active α-Glucosidase inhibitor with an IC50 of 18.1 μM. α-Glucosidase-IN-98 reversibly binds with α-Glucosidase via hydrogen bonds, electrostatic interactions and hydrophobic effects, which induces significant conformational alterations in the secondary structure of α-Glucosidase. α-Glucosidase-IN-98 decreases postprandial hyperglycemia in Starch (HY-B2225B) /Sucrose (HY-B1779) -challenged mice. α-Glucosidase-IN-98 can be used for type 2 diabetes mellitus (T2DM) research[1].

Product Specifications

UNSPSC

12352005

Target

Glycosidase

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Smiles

COC1=CC(CCC(CCC2=CC=C(C=C2)C#N)=O)=CC=C1O

Molecular Formula

C19H19NO3

Molecular Weight

309.36

References & Citations

[1]Liao XM, et al. Synthesis of diarylpentane derivatives as novel α-Glucosidase inhibitors: Their inhibitory mechanism and hypoglycemic effects. Eur J Med Chem. 2025 Dec 15;300:118161.