BRAFV600E/ABL2-IN-1
BRAFV600E/ABL2-IN-1 is a BRAFV600E (IC50 = 0.088 μM) /ABL2 (IC50 = 0.3 μM) dual inhibitor. BRAFV600E/ABL2-IN-1 can diminish P-glycoprotein expression. BRAFV600E/ABL2-IN-1 effectively inhibits p-CrkL (Abl2 signaling) and p-ERK1/2 (BRAFV600E pathway) in A375-R melanoma cells. BRAFV600E/ABL2-IN-1 causes cell cycle arrest at the G1 phase, inhibiting progression to the S phase and subsequent phases and G2/M phase. BRAFV600E/ABL2-IN-1 significantly increases the percentage of late apoptotic cells. BRAFV600E/ABL2-IN-1 can be used for the study of melanoma[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcr-Abl; PERK; P-glycoprotein; Raf
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(N/N=C(C1=CC=C(Br)C=C1)\C)CN2C(C3=CC=C(S(=O)(C)=O)C=C3)=NC4=CC(Cl)=CC=C24
Molecular Formula
C24H20BrClN4O3S
Molecular Weight
559.86
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf
Frequently Asked Questions
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