HDAC8-IN-14
HDAC8-IN-14, a curcuminoid derivative, is a selective HDAC8 inhibitor with a Ki of 9 nM. HDAC8-IN-14 induces the production of reactive oxygen species (ROS), disrupts mitochondrial membrane potential, and promotes apoptosis. HDAC8-IN-14 can significantly promote the accumulation of cells in the sub-G0/G1 phase, consistent with apoptotic or necrotic cell death. HDAC8-IN-14 induces upregulation of cytochrome c, cleaved caspase-3, and the pro-apoptotic protein Bak while leaving the anti-apoptotic Bcl-2 levels unaltered. HDAC8-IN-14 can be used for the study of leukemia[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Biochemical Assay Reagents; Caspase; HDAC; Necroptosis; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C1/C(CNC/C1=C\C2=CN(C3=CC=CC=C3)N=C2C4=CC=C(Cl)C=C4)=C/C5=CN(C6=CC=CC=C6)N=C5C7=CC=C(Cl)C=C7
Molecular Formula
C37H27Cl2N5O
Molecular Weight
628.55
References & Citations
[1]Sudarshan V, et al. Assessing the anti-leukemic efficacy of a curcuminoid in cellular and animal models. Eur J Med Chem. 2025 Dec 15;300:118177.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; HDAC8
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