Ferroptosis inducer-12

Ferroptosis inducer-12 is a potent and selective ferroptosis inducer. Ferroptosis inducer-12 exhibits potent antiproliferative activity against HT1080 and OS-RC-2, with IC50 values of 3 nM and 5 nM, respectively. Ferroptosis inducer-12 strongly inhibits GPX4 enzymatic activity, induces intracellular ROS and elevates intracellular Fe2+ levels in OS-RC-2 cells. Ferroptosis inducer-12 significantly inhibits tumor growth in BALB/c nude mice bearing OS-RC-2 xenografts. Ferroptosis inducer-12 can be used for the study of cancer[1].

Product Specifications

UNSPSC

12352005

Target

Ferroptosis; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

O=C(C#C)N([C@@H](C(OC)=O)C1)[C@@H](C2=CC=C(C(NCc3cccc3)=O)C=C2)C4=C1C5=CC=CC=C5N4.[][Fe][].c6cccc6

Molecular Formula

C34H29FeN3O4

Molecular Weight

599.46

References & Citations

[1]Wang J, et al. Structural optimization and biological evaluation of ferrocene-appended RSL3 derivatives as potent ferroptosis inducers. Eur J Med Chem. 2025 Sep 16;301:118162.