PFKFB4-IN-1
PFKFB4-IN-1 is a potent and selective ATP-competitive PFKFB4 inhibitor (IC50 = 4.50 μM) that reduces intracellular PFKFB4 protein levels. PFKFB4-IN-1 exhibits >12-fold selectivity over PFKFB1/4 and PFKFB3/4. PFKFB4-IN-1 inhibits cancer cell proliferation, induces apoptosis, and inhibits cell migration. PFKFB4-IN-1 inhibits tumor growth in the MDA-MB-231 xenograft mouse model. PFKFB4-IN-1 can be used for breast, lung and liver cancer research[1].
Product Specifications
CAS Number
2664831-55-2
UNSPSC
12352005
Target
Apoptosis; Caspase; PARP; Phosphatase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=[N+](C1=CC=C(O1)/C=N\NC2=CC=C(C3=NON=C23)[N+]([O-])=O)[O-]
Molecular Formula
C11H6N6O6
Molecular Weight
318.20
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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