PAC/NP-IN-1

PAC/NP-IN-1 (Compound 30) is a dual-target anti-influenza agent that specifically binds to nucleoprotein (NP) and the C-terminal domain of PA protein (PAc) . PAC/NP-IN-1 inhibits influenza A virus A/WSN/33 (H1N1) (EC50 = 3.63 μM, IC50 = 3.08 μM) . PAC/NP-IN-1 can be used for the study of influenza infection[1].

Product Specifications

UNSPSC

12352005

Target

Influenza Virus

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(C1=C(NC2=NC=NC3=CC=CC=C32)C=CC=C1)NCCN4CCN(C5=C(C)C=C(C)C=C5)CC4

Molecular Formula

C29H32N6O

Molecular Weight

480.60

References & Citations

[1]Zhang C, et al. Quinazoline-based dual-target inhibitors disrupt influenza virus RNP complex: Rational design, synthesis and mechanistic validation of potent anti-influenza agents. Eur J Med Chem. 2025 Sep 21;301:118185.