PAD-IN-4

PAD-IN-4 is a potent PAD inhibitor (PAD 1/4, IC50 = 0.273/0.24 μM) . PAD-IN-4 shows no significant cytotoxicity against A549 or MDA-MB-231 cells. PAD-IN-4 can be used for the study of cancer and autoimmune diseases[1].

Product Specifications

UNSPSC

12352005

Target

Protein Arginine Deiminase

Related Pathways

Epigenetics

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=C(N[C@@H](CCCNC(CCl)=N)C(NCC1=CC=CC=C1)=O)C2=CC=C3C=C(O)C=CC3=C2

Molecular Formula

C25H27ClN4O3

Molecular Weight

466.96

References & Citations

[1]Jia Y, et al. Discovery of highly potent naphthalene/quinoline-based PAD inhibitors: Structure-activity relationship, selectivity, and cytotoxicity. Eur J Med Chem. 2025 Oct 15;296:117830.