Anti-osteoporosis agent-12
Anti-osteoporosis agent-12 (Compound 18) is an orally active pyrazole-fused betulinic acid derivative with potent anti-osteoporosis activity. Anti-osteoporosis agent-12 exhibits a strong inhibitory effect on RANKL-induced osteoclastogenesis in RAW264.7 cells, with an IC50 of 7.96 nM. Anti-osteoporosis agent-12 can dose-dependently improve key micro-CT parameters of bone, reduce the level of serum bone resorption marker (CTx), and effectively prevent ovariectomy-induced bone loss. Anti-osteoporosis agent can be used for the study of osteoporosis[1].
Product Specifications
UNSPSC
12352005
Target
Drug Derivative
Related Pathways
Others
Field of Research
Metabolic Disease
Smiles
CC([C@@H]1CC[C@]2(C(OCCCCCC(NCCOCCOCCOCCO)=O)=O)CC[C@@]3(C)[C@]4(C)CCC5C(C)(C)C6=NNC=C6C[C@]5(C)C4CCC3C21)=C
Molecular Formula
C45H73N3O7
Molecular Weight
768.08
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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RCHY1 (RING Finger and CHY Zinc Finger Domain-containing Protein 1, Androgen Receptor N-terminal-interacting Protein, CH-rich-interacting Match with PLAG1, E3 Ubiquitin-protein Ligase Pirh2, RING Finger Protein 199, Zinc Finger Protein 363, p53-induced RING-H2 Protein, hPirh2, ARNIP, CHIMP, PIRH2, RNF199, ZNF363) (Biotin)
