EGFR/Cytokine-IN-1

EGFR/Cytokine-IN-1 is an EGFR (IC50 = 0.03 μM) and Cytokine inhibitor (TNF-α, IC50 = 3.1 μM; IL-6, IC50 = 1.6 ��M) . EGFR/Cytokine-IN-1 shows potent anticancer activity on A549 and MCF7, respectively. EGFR/Cytokine-IN-1 significantly reduces IL-6 and TNF-α levels in A549 cells, and also shows promising ADMET profiles. EGFR/Cytokine-IN-1 can induce apoptosis in a dose-dependent manner. compound 5h can be used for the study of breast cancer and lung cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; EGFR; Interleukin Related; TNF Receptor

Related Pathways

Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Smiles

N#CC1=C(C2=C(Cl)C=CC=C2)C=C(C3=CC=C(OC)C=C3)N=C1OCC(NC4=C(OC)C=CC=C4)=O

Molecular Formula

C28H22ClN3O4

Molecular Weight

499.94

References & Citations

[1]Lotfy EM, et al. Microwave-assisted one-pot green synthesis, ADMET profiling, DFT, and molecular docking of novel 3-cyano-2-pyridone derivatives as dual EGFR and cytokine (TNF-α, IL-6) inhibitors. Eur J Med Chem. 2025 Dec 15;300:118165.