MAO-B-IN-49

MAO-B-IN-49 is a selective and reversible MAO-B inhibitor (IC50 of 1 nM for human MAO-B) . MAO-B-IN-49 shows much higher selectivity for MAO-B than for MAO-A (IC50 = 633.9) . MAO-B-IN-49 can reduce ROS production induced by Lipopolysaccharides (HY-D1056) (LPS) in HT22 cells. MAO-B-IN-49 demonstrates substantial neuroprotective properties and significantly improves motor dysfunction in MPTP (HY-W114750) -induced mouse models of Parkinson’s disease (PD) . MAO-B-IN-49 can be used for the study of PD[1].

Product Specifications

CAS Number

[3098883-91-8]

UNSPSC

12352005

Target

Monoamine Oxidase; Reactive Oxygen Species (ROS)

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

C[C@H](N1CCOC2=C(C1)C=CC(OCC3=CC(F)=C(C=C3)F)=C2)C(N)=O

Molecular Formula

C19H20F2N2O3

Molecular Weight

362.37

References & Citations

[1]Zhu M, et al. Design, synthesis, and biological evaluation of highly potent and selective hMAO-B inhibitors featuring a tetrahydrobenzo[f][1,4]oxazepine core. Eur J Med Chem. 2025 Dec 5;299:118080.