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P-gp inhibitor 30

P-gp inhibitor 30 is a potent P-gp inhibitor that reverses multidrug resistance in breast cancer by sensitizing resistant cells to Doxorubicin (ADM). P-gp inhibitor 30 promotes apoptosis, induces autophagy, and suppresses proliferation, migration, and invasion of drug-resistant breast cancer cells when combined with ADM. P-gp inhibitor 30 inhibits breast tumor growth both in vitro and in vivo. P-gp inhibitor 30 can be used for drug-resistant breast cancer research[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Autophagy; P-glycoprotein

Related Pathways

Apoptosis; Autophagy; Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

N#CC1=CC(NC(C2=NNC3=C2C=CC=C3)=O)=CC=C1OCC4=C(C=CC=C4)F

Molecular Formula

C22H15FN4O2

Molecular Weight

386.38

References & Citations

[1]Xue WH, et al. Discovery of a heterocyclic aromatic amide based P-gp inhibitor as coadjutant regulating autophagy against drug resistance in breast cancer. Eur J Med Chem. 2025 Dec 15;300:118151.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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