PARP1/c-Met-IN-2
PARP1/c-Met-IN-2 is a highly potent, orally active, PARP1 (IC50 = 21.8 nM) and c-Met (IC50 = 30.2 nM) dual inhibitor. PARP1/c-Met-IN-2 can elevate the expression level of γH2AX, cause DNA damage. PARP1/c-Met-IN-2 exhibits remarkable anti-tumor efficacy in the Olaparib -resistant HCT116 (HCT116OR) xenograft models. PARP1/c-Met-IN-2 can be used for the study of Colon Cancer[1].
Product Specifications
UNSPSC
12352005
Target
C-Met/HGFR; DNA/RNA Synthesis; PARP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
N#CC1=CC(C2=NN(C(C=C2)=O)CCOC3=C4C=CC(N5CCN(CC5)C(C6=CC7=C(C(C(N)=O)=CC=C7)O6)=O)=CC4=NC=C3)=CC=C1.Cl
Molecular Formula
C36H30ClN7O5
Molecular Weight
676.12
References & Citations
[1]Sun Z, et al. Discovery of a novel benzofuran-7-carboxamide-based PARP1/c-Met dual inhibitor for addressing c-Met amplification-mediated PARP1i acquired-resistance. Eur J Med Chem. 2025 Dec 15;300:118164.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Met; PARP1
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