Aurora A-IN-5
Aurora A-IN-5 is a potent and highly selective Aurora A inhibitor (IC50 = 0.02 μM), showing 362-fold selectivity for over Aurora B. Aurora A-IN-5 shows its selectivity through unique C−H/π interactions, enhanced hydrophobic contacts, an open binding pocket, and tighter protein packing. Aurora A-IN-5 suppresses Aurora A autophosphorylation, thereby inhibiting cancer cell proliferation by inducing G2/M phase arrest, triggering apoptosis, and suppressing colony formation. Aurora A-IN-5 inhibits tumor growth in MDA-MB-231 xenograft mouse models. Aurora A-IN-5 can be used for breast, cervical, prostate, and lymphoma cancer research[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Aurora Kinase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
CN1CCN(C2=CC3=NC(C4=CC=CC(OC)=C4OC)=NC(NC5=NNC(C)=C5)=C3C=C2)CC1
Molecular Formula
C25H29N7O2
Molecular Weight
459.54
References & Citations
[1]Long L, et al. Discovery of a Potent and Highly Selective Inhibitor of Aurora A Kinase. ACS Med Chem Lett. 2025 Sep 17;16 (10) :2057-2069.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-178343/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A
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