NNRT-IN-13
NNRT-IN-13 is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor that directly inhibiting HIV-1 reverse transcriptase (IC₅₀ = 0.25 μM) . NNRT-IN-13 exhibits excellent antiviral activity against wild-type HIV-1 (EC₅₀ = 0.0046 μM) and a broad spectrum of drug-resistant mutants. NNRT-IN-13 exhibits favorable in vivo metabolic and safety profiles. NNRT-IN-13 can be used for human immunodeficiency virus (HIV) research[1].
Product Specifications
UNSPSC
12352005
Target
HIV; Reverse Transcriptase
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=S(C1=CC=C(CN2CCC(NC3=NC(OC4=C(C=C(C=C4C)/C=C/C#N)C)=CC(NCC5=COC=N5)=N3)CC2)C=C1)(N)=O
Molecular Formula
C31H34N8O4S
Molecular Weight
614.72
References & Citations
[1]Ji X, et al. Exploring the HIV-1 Reverse Transcriptase p51/p66 Interface: Structure-Based Design and Optimization of Novel 2,4,6-Trisubstituted Pyrimidines as Potent NNRTIs with Improved Resistance Profiles. J Med Chem. 2025 Oct 9;68 (19) :20519-20535.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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