Antifungal agent 137

Antifungal agent 137 (Compound 4S) is an antifungal agent. Antifungal agent 137 inhibits Phomopsis sp. (PS), with an EC50 of 0.15 μg/mL. Antifungal agent 137 inhibits lanosterol 14α-demethylase (CYP51), with an IC50 of 5.00 μg/mL. Antifungal agent 137 disrupts the morphology of PS mycelia, impairs cell membrane integrity, and induces an increase in intracellular ROS levels, triggering oxidative stress. Antifungal agent 137 can be used for the study of fungal infection[1].

Product Specifications

CAS Number

[3032062-22-6]

UNSPSC

12352005

Target

Cytochrome P450; Fungal; Reactive Oxygen Species (ROS)

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Infection

Smiles

OC(CN1N=CN=C1)(C2=CC=C(F)C=C2F)CN3CCN(S(=O)(C4=CC(F)=CC=C4F)=O)CC3

Molecular Formula

C21H21F4N5O3S

Molecular Weight

499.48

References & Citations

[1]Wu W, et al. Novel 1,2,4-Triazole Derivatives Containing a Benzenesulfonamide Moiety as Potential Antifungal Agents for Controlling Postharvest Soft Rot in Kiwifruit. J Agric Food Chem. 2025 Oct 1;73 (39) :24549-24560.