HDAC6-IN-66

HDAC6-IN-66 is a potent and selective histone deacetylase (HDAC) 6 inhibitor with an IC50 of 1.8 nM. HDAC6-IN-66 induces α-tubulin acetylation over histone H3. HDAC6-IN-66 can be used for the research of cancer[1].

Product Specifications

CAS Number

[3095060-23-1]

UNSPSC

12352005

Target

HDAC

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(NO)C1=CC=C(CN2N=C(C3=CC=CO3)C4=C2C=CC=C4)C=C1

Molecular Formula

C19H15N3O3

Molecular Weight

333.34

References & Citations

[1]Ali KH, et al. Design, synthesis, and biological evaluation of indazole-based histone deacetylase 6 inhibitors. Eur J Med Chem. 2025 Oct 5;295:117785.