IKE16
IKE16 is a fungi-selective eukaryotic topoisomerase II inhibitor, with an IC50 value of 13.68 μM. IKE16 suppresses both the DNA relaxation activity and the decatenation activity of yTOPOII selectively. IKE16 shows moderate activity against standard fungal strains (Candida albicans ATCC 10231, Saccharomyces cerevisiae ATCC 89763) with a minimum inhibitory concentration (MIC) of 2 μg/mL against S. cerevisiae ATCC 89763. IKE16 exhibits high cytotoxicity against human cells, with an EC50 of 0.07 μM in HepG2 and 0.045 μM in HEK-293. IKE16 can be used for the study of antifungal infection[1].
Product Specifications
UNSPSC
12352005
Target
Others; Topoisomerase
Related Pathways
Cell Cycle/DNA Damage; Others
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
O=[N+](C1=CC=CC2=NC3=CC=CC=C3C(NCCCN4CCN(CCCNC5=C(C([N+]([O-])=O)=CC=C6)C6=NC7=CC=CC=C75)CC4)=C21)[O-]
Molecular Formula
C36H36N8O4
Molecular Weight
644.72
References & Citations
[1]Kondaka K, et al. Bisacridine derivatives as effective eukaryotic topoisomerase II inhibitors. Eur J Med Chem. 2025 Sep 18;301:118174.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II
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