VDR agonist 4
VDR agonist 4 is an orally active potent VDR agonist. VDR agonist 4 exerts VDR-dependent antifibrotic activity by regulating multiple fibrosis-related genes to suppress α-SMA and collagen I production, thereby inhibiting hepatic stellate cell (HSC) activation. VDR agonist 4 improves CCl4 (HY-RS16594) -induced hepatic fibrosis in mice. VDR agonist 4 can be used for liver fibrosis research[1].
Product Specifications
UNSPSC
12352005
Target
Collagen; JAK; MMP; TGF-beta/Smad; VD/VDR
Related Pathways
Cytoskeleton; Epigenetics; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; TGF-beta/Smad; Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology; Metabolic Disease; Inflammation/Immunology
Smiles
CCN(C(CCCCCOC1=CC2=CC=C(C=C2C=C1)OCC3=C[C@H]([C@H]([C@@H](C3)O)O)O)=O)CC
Molecular Formula
C27H37NO6
Molecular Weight
471.59
References & Citations
[1]Gao Y, et al. Design, Synthesis, and Evaluation of Antifibrotic Activity of Nonsteroidal VDR Agonists Featuring 1,6-Naphthol as a CD-Ring Surrogate. J Med Chem. 2025 Oct 9;68 (19) :20561-20585.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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