Tubulin-IN-57

Tubulin-IN-57 is a Tubulin inhibitor. Tubulin-IN-57 is a potent antiproliferative agent that inhibits clonogenic formation, migration, and invasion of ovarian cancer cells. Tubulin-IN-57 inhibits tubulin polymerization, which in turn induces G2/M arrest and apoptosis in SKOV3 cells. Tubulin-IN-57 demonstrates potent antitumor activity without observable toxicity in an SKOV3 xenograft model. Y60S can be used for the study of ovarian cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Smiles

CCOC1=CC=C(C=C1)C2=C3C(C(N([C@@H]3C4=CC=CC=C4OC)CC5=CC=NC=C5)=O)=NN2

Molecular Formula

C26H24N4O3

Molecular Weight

440.49

References & Citations

[1]Yu Q, et al. Discovery of Novel 4,5-Dihydropyrrolo[3,4-c]pyrazol-6 (2H) -one-Based Tubulin Inhibitors Targeting Colchicine Binding Site with Potent Anti-Ovarian Cancer Activity. J Med Chem. 2025 Oct 9;68 (19) :19908-19932.