Tubulin-IN-57
Tubulin-IN-57 is a Tubulin inhibitor. Tubulin-IN-57 is a potent antiproliferative agent that inhibits clonogenic formation, migration, and invasion of ovarian cancer cells. Tubulin-IN-57 inhibits tubulin polymerization, which in turn induces G2/M arrest and apoptosis in SKOV3 cells. Tubulin-IN-57 demonstrates potent antitumor activity without observable toxicity in an SKOV3 xenograft model. Y60S can be used for the study of ovarian cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Smiles
CCOC1=CC=C(C=C1)C2=C3C(C(N([C@@H]3C4=CC=CC=C4OC)CC5=CC=NC=C5)=O)=NN2
Molecular Formula
C26H24N4O3
Molecular Weight
440.49
References & Citations
[1]Yu Q, et al. Discovery of Novel 4,5-Dihydropyrrolo[3,4-c]pyrazol-6 (2H) -one-Based Tubulin Inhibitors Targeting Colchicine Binding Site with Potent Anti-Ovarian Cancer Activity. J Med Chem. 2025 Oct 9;68 (19) :19908-19932.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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