OUL312

OUL312 is a potent PARP10 inhibitor (IC50 = 20 nM), showing more than 75-fold greater selectivity for PARP15 (IC50 = 1500 nM) . OUL312 is also at least 18-fold higher than all other human enzymes in the family. OUL312 has a good ADME profile, is able to enter cells, is not toxic, and effectively rescues human cells from PARP10-induced apoptosis at sub-micromolar concentrations. OUL312 can be used for the study of cervical cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; PARP

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer; Infection; Inflammation/Immunology

Purity

99.20

Smiles

O=C1NNC(C2=C1C=CC(OCCC3=CC=CC=C3F)=C2)=O

Molecular Formula

C16H13FN2O3

Molecular Weight

300.28

References & Citations

[1]Alaviuhkola J, et al. Optimization of 2,3-dihydrophthalazine-1,4-dione PARP inhibitor scaffold for nanomolar potency and specificity towards human PARP10. Eur J Med Chem. 2025 Dec 15;300:118111.