OUL312
OUL312 is a potent PARP10 inhibitor (IC50 = 20 nM), showing more than 75-fold greater selectivity for PARP15 (IC50 = 1500 nM) . OUL312 is also at least 18-fold higher than all other human enzymes in the family. OUL312 has a good ADME profile, is able to enter cells, is not toxic, and effectively rescues human cells from PARP10-induced apoptosis at sub-micromolar concentrations. OUL312 can be used for the study of cervical cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; PARP
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer; Infection; Inflammation/Immunology
Purity
99.20
Smiles
O=C1NNC(C2=C1C=CC(OCCC3=CC=CC=C3F)=C2)=O
Molecular Formula
C16H13FN2O3
Molecular Weight
300.28
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP10
Available Sizes
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