EGFR ligand-18

EGFR ligand-18 is a PROTAC target protein ligand that can be used for synthesis of PROTACs, such as PROTAC EGFR degrader 16 (HY-178242) . PROTAC EGFR degrader 16 is a potent EGFR PROTAC degrader with anti-tumor activity[1].

Product Specifications

UNSPSC

12352005

Target

EGFR; Ligands for Target Protein for PROTAC

Related Pathways

JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(NC1=NC=CS1)C(C2=C(CCC3)N3C=N2)N(CC4=C5C=C(C6=CC=CC=C6)C=C4F)C5=O

Molecular Formula

C25H20FN5O2S

Molecular Weight

473.52

References & Citations

[1]Christopher G, et al. EGFR DEGRADERS TO TREAT CANCER METASTASIS TO THE BRAIN OR CNS CROSS-REFERENCE TO RELATED APPLICATIONS. WO2022251539.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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