VHR-IN-9

VHR-IN-9 is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC50 of 270 nM. VHR-IN-9 shows very weaker inhibitory activity against MKP-1 (IC50 = 2.8 μM), CD45 (IC50 = 1.8 μM), Cdc25A (IC50 = > 10 μM), PTP1B (IC50 = 2.2 μM), and HePTP (IC50 = 2.4 μM) . VHR-IN-9 inhibits the proliferation of HeLa cells. VHR-IN-9 can be used for the research of cervical cancer[1].

Product Specifications

CAS Number

[1146616-18-3]

UNSPSC

12352005

Target

Phosphatase

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=S(C(C=C1)=CC=C1C2=NN(C3=CC=CC=C3)C=C2/C=C4C(N(C(S/4)=S)CCS(=O)(O)=O)=O)(N5CCCCC5)=O

Molecular Formula

C26H26N4O6S4

Molecular Weight

618.77

References & Citations

[1]Wu S, et al. Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells. J Med Chem. 2009 Nov 12;52 (21) :6716-23.