VHR-IN-5

VHR-IN-5 is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC50 of 78 nM. VHR-IN-5 shows very weaker inhibitory activity against MKP-1 (IC50 = 0.78 μM), CD45 (IC50 = 0.61 μM), Cdc25A (IC50 = 3.4 μM), PTP1B (IC50 = 1.8 μM), and HePTP (IC50 = 1.5 μM) . VHR-IN-5 inhibits the proliferation of HeLa cells. VHR-IN-5 can be used for the research of cervical cancer[1].

Product Specifications

CAS Number

[956442-05-0]

UNSPSC

12352005

Target

Phosphatase

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(N(C(S/1)=S)CCS(=O)(O)=O)C1=C\C2=CN(C3=CC=CC=C3)N=C2C4=CC=C(C=C4)OCC5=CC=CC=C5

Molecular Formula

C28H23N3O5S3

Molecular Weight

577.69

References & Citations

[1]Wu S, et al. Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells. J Med Chem. 2009 Nov 12;52 (21) :6716-23.