VHR-IN-3

VHR-IN-3 (Compound 1) is a selective vaccinia H1-related (VHR) phosphatase inhibitor with a Ki of 0.81 μM. VHR-IN-3 mimics the phosphate group through the sulfonic acid group and competitively binds to the catalytic active center of VHR. VHR-IN-3 can be used for the research of cervical cancer[1].

Product Specifications

CAS Number

[1191105-54-0]

UNSPSC

12352005

Target

Phosphatase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

O=C(N(C(S/1)=S)CCS(=O)(O)=O)C1=C\C=C\C2=CC=CC=C2

Molecular Formula

C14H13NO4S3

Molecular Weight

355.45

References & Citations

[1]Wu S, et al. Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells. J Med Chem. 2009 Nov 12;52 (21) :6716-23.