TNF-α-IN-27

TNF-α-IN-27 (Compound 1) is a TNF-α inhibitor with inhibition rate of 64% at 10 μM. TNF-α-IN-27 can be used for the researches of inflammation and immunology, such as asthma[1].

Product Specifications

CAS Number

[340307-20-2]

UNSPSC

12352005

Target

TNF Receptor

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C(C1=C(Cl)C=C(C2=CC=C(/C=C3C(NC(N(C4=CC=CC(C)=C4)C\3=O)=O)=O)O2)C=C1)O

Molecular Formula

C23H15ClN2O6

Molecular Weight

450.83

References & Citations

[1]Choi H, et al. Discovery of the inhibitors of tumor necrosis factor alpha with structure-based virtual screening. Bioorg Med Chem Lett. 2010 Nov 1;20 (21) :6195-8.