EGFR-IN-177
EGFR-IN-177 is a potent EGFR inhibitor with IC50s of 0.32, 1.04, 0.65, 0.67, 0.48, 0.55 and 0.38 nM against EGFR L858R, EGFR L858R/T790M, EGFR L858R/T790M/C797S, EGFR D746-750, EGFR D746-750/C797S, EGFR D770_N77linsNPG, and EGFR WT. EGFR-IN-177 inhibits lung cancer proliferation and EGFR phosphorylation. EGFR-IN-177 can be used for the study of cancers such as non-small cell lung cancer[1].
Product Specifications
CAS Number
[3062177-59-4]
UNSPSC
12352005
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
OC[C@@H](N1C2=C(/C=C/C(C3=CC(C4=C(N(N=C4C)C)O[C@H](CN(C2)C)C)=N5)=NNC3=C5C)C(OCC)=N1)C
Molecular Formula
C27H36N8O3
Molecular Weight
520.63
References & Citations
[1]Jingrong Jean Cui, et al. EGFR inhibitors for treating disease. WO2024229091.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
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