JAK1-IN-19

JAK1-IN-19 (Compound 18) is a potent JAK1 inhibitor with IC50s of 0.02, 0.5, 91 and 0.2 nM against JAK1, JAK2, JAK3 and TYK2. JAK1-IN-19 exhibits improved rat and human intrinsic clearance. JAK1-IN-19 can be used for the studies of atopic dermatitis and other autoimmune diseases[1].

Product Specifications

CAS Number

[2169271-17-2]

UNSPSC

12352005

Target

JAK

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Inflammation/Immunology

Smiles

N#C[C@@H]1[C@H](COCC1)N2N=C(C(C(N)=O)=C2)NC3=CC=C(C4=CN(N=C4)C)C=C3

Molecular Formula

C20H21N7O2

Molecular Weight

391.43

References & Citations

[1]Siu T, et al. The Discovery of 3- ((4-Chloro-3-methoxyphenyl) amino) -1- ((3R,4S) -4-cyanotetrahydro-2H-pyran-3-yl) -1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties. J Med Chem. 2017 Dec 14;60 (23) :9676-9690.