JAK1-IN-19
JAK1-IN-19 (Compound 18) is a potent JAK1 inhibitor with IC50s of 0.02, 0.5, 91 and 0.2 nM against JAK1, JAK2, JAK3 and TYK2. JAK1-IN-19 exhibits improved rat and human intrinsic clearance. JAK1-IN-19 can be used for the studies of atopic dermatitis and other autoimmune diseases[1].
Product Specifications
CAS Number
2169271-17-2
UNSPSC
12352005
Target
JAK
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Smiles
N#C[C@@H]1[C@H](COCC1)N2N=C(C(C(N)=O)=C2)NC3=CC=C(C4=CN(N=C4)C)C=C3
Molecular Formula
C20H21N7O2
Molecular Weight
391.43
References & Citations
[1]Siu T, et al. The Discovery of 3- ((4-Chloro-3-methoxyphenyl) amino) -1- ((3R,4S) -4-cyanotetrahydro-2H-pyran-3-yl) -1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties. J Med Chem. 2017 Dec 14;60 (23) :9676-9690.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK1; JAK2; JAK3; Tyk2
Frequently Asked Questions
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