Exatecan-3-amine

Exatecan-3-amine is an effective exatecan derivative. Exatecan-3-amine can be connected to monoclonal antibodies via linkers to form antibody-drug conjugate (ADC) molecules. Exatecan-3-amine is often combined with CLDN6 mAb to form ADC drugs for the study of tumors with high expression of CLDN6[1].

Product Specifications

CAS Number

[3035271-49-6]

UNSPSC

12352005

Target

ADC Payload

Related Pathways

Antibody-drug Conjugate/ADC Related

Field of Research

Cancer

Smiles

N[C@H]1C2=C3C(CC1)=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC3=CC(F)=C2C

Molecular Formula

C24H22FN3O4

Molecular Weight

435.45

References & Citations

[1]Runsheng LI, et al. Preparation of antibodies and antibody-drug conjugates specific to human claudin 6 and their uses for treatment of cancers. WO2024165057.