(R) -thioxo-Dxd

(R) -thioxo-Dxd is a Camptothecin derivative. (R) -thioxo-Dxd can be connected to monoclonal antibodies via linkers to form antibody-drug conjugate (ADC) molecules. (R) -thioxo-Dxd can be used for research on tumors with high HER2 or TROP2 expression[1].

Product Specifications

CAS Number

2806052-36-6

UNSPSC

12352005

Target

ADC Payload

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

OCC(N[C@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=S)=NC6=CC(F)=C(C)C(CC1)=C62)=O

Molecular Formula

C26H24FN3O5S

Molecular Weight

509.55

References & Citations

[1]Ao Li, et al. Ligand conjugate compounds as antitumor agents and their preparation, pharmaceutical compositions and use in the treatment of cancer. WO2022262789.